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Hippocampal network activity in the physiological context and in the context of epilepsy and of anti-depressive electro-convulsive treatment is a potent stimulator of adult hippocampal neurogenesis

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Thus, worldwide drug development efforts need re-evaluation and new strategies given that current efforts have been unsuccessful

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found that fast escalation to 8 mg produced GI adverse events in 50% of participants, compared to roughly 35% with gradual titration (Rosenstock et al., Lancet, 2023)